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brca1 cancersbrca1 pancreatic cancerbrca1 tumor suppressorbrca1 prostate cancerbrca1 ovarian cancerbrca1 and brca2 mutationsbrca1 breast cancerbrca1 colon cancerbrca1 gene mutationbrca1 and brca2 breast cancerbrca1 tumor suppressor genebrca mutation ovarian cancer