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myeloma relapse symptomsrelapsed refractory multiple myelomarelapsed multiple myeloma prognosismultiple myeloma relapse ratesymptomatic multiple myelomaselinexor multiple myelomaisatuximab multiple myelomamyeloma multiple diagnosisrecurrent multiple myelomamultiple myeloma refractorypomalidomide multiple myelomaimmunotherapy in multiple myeloma