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metastatic breast cancer signstage 2 breast cancer metastasisearly stage inflammatory breast canceradvanced stage breast cancerstage 4 breast cancer survivorsadvanced metastatic breast cancerstage 4 lobular breast cancersurvival for stage 4 breast cancerstage 4 metastatic melanoma cancermetastatic breast cancer supportmetastatic carcinoma breast cancermetastatic breast cancer prognosis