high von willebrand factorvon willebrand disease pathophysiologyvon willebrand factor deficiencyacquired von willebrand diseaseelevated von willebrand factorvon willebrand disordervon willebrand factor numbervon willebrand disease dobermanhemophilia von willebrand diseasevon willebrand syndromepseudo von willebrand diseasevon willebrand disease medscape