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high von willebrand factorvon willebrand disease pathophysiologyvon willebrand factor deficiencyvon willebrand disease inheritanceacquired von willebrand diseaseelevated von willebrand factorvon willebrand disordervon willebrand factor numbervon willebrand disease dobermanhemophilia von willebrand diseasevon willebrand syndromepseudo von willebrand disease